Effect of meloxicam coadministration on the anaesthetic potency of thiopental sodium in a chick model

Few studies have dealt with thiopental sodium-induced anaesthetic action and the effect of combining meloxicam (a high plasma protein-bound) in 10–15 day old chicks. First, analgesic median effective dose (ED50) was determined as 35.85 mg/kg, IM by up-and-down routine, while hypnotic ED50 value 34.40 chick model. A sodium injection (18, 36 72 IM) produces a significant dose-responsive chicks, beginning lack righting reflex, duration recovery time. Thiopental (72 1 combination shortened hypnosis, significantly extended its duration, increase time from when compared to group receiving only sodium. The same also elicited percentage efficacy, voltage current estimated via using electrical stimulation induce ache feeling. No changes were found concentrations serum glutamate pyruvate trans-aminase (GPT), oxalo-acetate (GOT) body temperature between two groups, exception change respiratory rate. outcomes this study support prospect an agent for veterinary surgical procedures meloxicam, produce worthy, consistent, proficient anaesthesia.